Name | 2-(4-Fluorophenyl)thiophene |
Synonyms | T5SJ BR DF [WLN] 2-(4-Fluorphenyl)thiophen Thiophene, 2-(4-fluorophenyl)- |
CAS | 58861-48-6 |
InChI | InChI=1/C10H7FS/c11-9-5-3-8(4-6-9)10-2-1-7-12-10/h1-7H |
Molecular Formula | C10H7FS |
Molar Mass | 178.22 |
Density | 1.201g/cm3 |
Melting Point | 51.0-55.0℃ |
Boling Point | 252.316°C at 760 mmHg |
Flash Point | 106.397°C |
Vapor Presure | 0.031mmHg at 25°C |
Storage Condition | 2-8℃ |
Refractive Index | 1.578 |
MDL | MFCD06802535 |
Use | This product is for scientific research only and shall not be used for other purposes. |
дёӯж–ҮеҗҚз§°: | 2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ© |
дёӯж–ҮеҗҢд№үиҜҚ: | 2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©;еҚЎжјеҲ—еҮҖ,еқҺжјеҲ—еҮҖжүӢжҖ§ејӮжһ„дҪ“жқӮиҙЁ;2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ© 1KG;2-(еҜ№ж°ҹиӢҜеҹә)-еҷ»еҗ©;еҚЎжјеҲ—еҮҖдёӯй—ҙдҪ“:2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©;еҚЎжјеҲ—еҮҖдёӯй—ҙдҪ“(CAR-4);2-(5-зўҳ-2-з”ІеҹәиӢҜз”Ій…°еҹә)-5-еҜ№ж°ҹиӢҜеҹәеҷ»еҗ©;2-иӢҜеҹә-5-[(5-зўҳ-2-з”ІеҹәиӢҜеҹә)з”Іеҹә]еҷ»еҗ© |
иӢұж–ҮеҗҚз§°: | 2-(4-FLUOROPHENYL)THIOPHENE |
иӢұж–ҮеҗҢд№үиҜҚ: | IFLAB-BB F2108-0130;2-(4-FLUOROPHENYL)THIOPHENE;AKOS BAR-1344;Thiophene, 2-(4-fluorophenyl)-;Canagliflozin intermediate;Canagliflozin Intermediate I;Canagliflozin INT2;2-(4-fluorophenyl)thiophen |
CASеҸ·: | 58861-48-6 |
еҲҶеӯҗејҸ: | C10H7FS |
еҲҶеӯҗйҮҸ: | 178.23 |
EINECSеҸ·: | 611-756-1 |
зӣёе…ізұ»еҲ«: | жңүжңәй“қеҢ–еҗҲзү©;еҚЎжјеҲ—еҮҖдёӯй—ҙдҪ“;еҷ»еҗ©;еқҺжјеҲ—еҮҖдёӯй—ҙдҪ“;еҷ»еҗ©зі»еҲ—;жңүжңәжқӮзҺҜ;еҢ»иҚҜдёӯй—ҙдҪ“;еҢ»иҚҜеҺҹж–ҷ;жңүжңәдёӯй—ҙдҪ“;еҢ–еӯҰдёӯй—ҙдҪ“;еҗҲжҲҗдёӯй—ҙдҪ“;жңүжңәеҢ–е·ҘеҺҹж–ҷ;еҢ–е·ҘеҺҹж–ҷ;дёӯй—ҙдҪ“-жңүжңәдёӯй—ҙдҪ“;жҠ—зі– |
Molж–Ү件: | 58861-48-6.mol |
зҶ”зӮ№ | 51.0 to 55.0 В°C |
жІёзӮ№ | 252.3Вұ15.0 В°C(Predicted) |
еҜҶеәҰ | 1.200Вұ0.06 g/cm3(Predicted) |
еӮЁеӯҳжқЎд»¶ | 2-8В°C(protect from light) |
жә¶и§ЈеәҰ | soluble in Methanol |
еҪўжҖҒ | powder to crystal |
йўңиүІ | Light orange to Yellow to Green |
жҰӮиҝ° | 2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©жҳҜеҗҲжҲҗеқҺжјеҲ—еҮҖзҡ„дёӯй—ҙдҪ“пјҢеқҺжјеҲ—еҮҖ(CanagliflozinпјҢе•Ҷе“ҒеҗҚInvokana)жҳҜйҰ–дёӘиҺ·жү№зҡ„й’и‘Ўиҗ„зі–еҚҸеҗҢиҪ¬иҝҗиӣӢ зҷҪ2(SGLT2)жҠ‘еҲ¶еүӮпјҢдәҺ2013е№ҙ3жңҲиҺ·еҫ—зҫҺеӣҪFDAзҡ„жү№еҮҶз”ЁдәҺ2еһӢзі–е°ҝз—…жІ»з–—гҖӮCanagliflozinжҳҜиҝ‘е№ҙжқҘдёҙеәҠж•ҲжһңжңҖеҘҪзҡ„жҠ—зі–е°ҝз—…ж–°иҚҜд№ӢдёҖгҖӮ2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©жҳҜиҜҘеҢ–еҗҲзү©еҗҲжҲҗиҝҮзЁӢдёӯзҡ„йҮҚиҰҒдёӯй—ҙдҪ“гҖӮ2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©жҳҜеҗҲжҲҗжҠ—зі–е°ҝз—…иҚҜзү©Canagliflozinзҡ„йҮҚиҰҒдёӯй—ҙдҪ“пјҢжүҖд»ҘйңҖиҰҒеҜ№зІ—дә§е“Ғ2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©иҝӣиЎҢзәҜеҢ–гҖӮиҜҘеҢ–еҗҲзү©зү©зҗҶжҖ§иҙЁзү№ж®ҠпјҢеёёжё©дёӢдёәзҷҪиүІеӣәдҪ“пјҢеҠзғӯжқЎд»¶дёӢдёәж¶ІдҪ“гҖӮеӣжӯӨпјҢйҡҫд»ҘеҲҶзҰ»жҸҗзәҜгҖӮдјз»ҹзҡ„жҹұеұӮжһҗеҲҶзҰ»ж–№жі•пјҢж“ҚдҪңз№ҒзҗҗпјҢиҖ—ж—¶иҫғй•ҝпјҢдё”дёҚеҲ©дәҺе·ҘдёҡеҢ–з”ҹдә§гҖӮзӣ®еүҚпјҢеӣҪеҶ…еӨ–е…ідәҺеҗҲжҲҗиҜҘеҢ–еҗҲзү©зҡ„ж–ҮзҢ®дёӯд»…жҸҗеҲ°еҲ©з”ЁжҹұеұӮжһҗеҲҶзҰ»иҜҘеҢ–еҗҲзү©пјҢеҸҜжҳҜиҜҘж–№жі•ж“ҚдҪңз№ҒзҗҗпјҢдёҚжҳ“е·ҘдёҡеҢ–з”ҹдә§гҖӮ |
еҗҲжҲҗж–№жі• | 1пјү4-ж°ҹиӢҜд№ҷй…®еңЁеӣәдҪ“дёүе…үж°”е’ҢNпјҢN-дәҢз”Іеҹәз”Ій…°иғәзҡ„дҪңз”ЁдёӢеҸ‘з”ҹVilsmeier- HaackеҸҚеә”пјҢз»ҸиҝҮеҠж°ҙеҲҶеұӮпјҢзўұеҢ–пјҢжҠҪж»ӨпјҢе№ІзҮҘеҫ—еҲ°3-ж°Ҝ-3-(4-ж°ҹиӢҜеҹә)дёҷзғҜйҶӣпјӣ иҝӣдёҖжӯҘзҡ„пјҢ4-ж°ҹиӢҜд№ҷй…®гҖҒеӣәдҪ“дёүе…үж°”е’ҢNпјҢN-дәҢз”Іеҹәз”Ій…°иғәзҡ„ж‘©е°”жҜ”дёәпјҡ1пјҡ0.4пҪһ 1.0пјҡ1.2пҪһ3.0гҖӮиҝӣдёҖжӯҘзҡ„пјҢиҜҘеҸҚеә”дҪ“зі»дёӯиҝҳеҢ…жӢ¬5пҪһ15еҖҚдәҺ4-ж°ҹиӢҜд№ҷй…®иҙЁйҮҸзҡ„жә¶еүӮпјҢе…¶дёӯжә¶еүӮпјҡ4- ж°ҹиӢҜд№ҷй…®иҙЁйҮҸпјқmLпјҡgпјҢжүҖиҝ°жә¶еүӮдёәдәҢж°Ҝз”Ізғ·гҖҒж°Ҝд»ҝгҖҒеӣӣж°ҜеҢ–зўіе’Ң1пјҢ2-дәҢж°Ҝд№ҷзғ·дёӯд»»ж„ҸдёҖз§ҚгҖӮиҝӣдёҖжӯҘзҡ„пјҢеҸҚеә”жүҖз”ЁTriphosgene/DMFиҜ•еүӮпјҢиҝҳеҸҜд»Ҙз”ЁPOCl3/DMFпјҢ(COCl)2/DMпјҢSOCl2/DMFзӯүиҜ•еүӮд»ЈжӣҝиҝӣиЎҢVilsmeier-HaackеҸҚеә”пјӣиҝӣдёҖжӯҘзҡ„пјҢеҸҚеә”жё©еәҰдёә0в„ғпҪһ25в„ғгҖӮ 2пјү3-ж°Ҝ-3-(4-ж°ҹиӢҜеҹә)дёҷзғҜйҶӣеңЁзўұзҡ„дҪңз”ЁдёӢе’Ңе·Ҝеҹәд№ҷй…ёд№ҷй…ҜеҸ‘з”ҹе…ізҺҜеҸҚеә”пјҢз»ҸеҠж°ҙпјҢжҠҪж»ӨпјҢеҫ—еҲ°5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-зҫ§й…ёд№ҷй…ҜпјӣиҝӣдёҖжӯҘзҡ„пјҢиҜҘеҸҚеә”дёӯзҡ„е·Ҝеҹәд№ҷй…ёд№ҷй…Ҝзҡ„й…ҜеҹәйғЁеҲҶеҸҜиў«C1пҪһC5зҡ„зӣҙй“ҫжҲ–иҖ…еҗ«ж”Ҝй“ҫзҡ„йҶҮеҸ–д»ЈпјҢе·Ҝеҹәд№ҷй…ёд№ҷй…ҜжҲ–иҖ…й…ҜеҹәйғЁеҲҶиў«еҸ–д»Јзҡ„е·Ҝеҹәд№ҷй…ёд№ҷй…Ҝзҡ„ж‘©е°”з”ЁйҮҸдёә3-ж°Ҝ-3-(4-ж°ҹиӢҜеҹә)дёҷзғҜйҶӣзҡ„1пҪһ1.5еҖҚгҖӮиҝӣдёҖжӯҘзҡ„пјҢзўұзҡ„ж‘©е°”з”ЁйҮҸдёә3-ж°Ҝ-3-(4-ж°ҹиӢҜеҹә)дёҷзғҜйҶӣзҡ„1пҪһ3еҖҚгҖӮзўұеҸҜд»ҘжҳҜж—жңә зўұпјҢеҰӮзўій…ёй’гҖҒзўій…ёй’ҫгҖҒд№ҷйҶҮй’гҖҒз”ІйҶҮй’гҖҒж°ўж°§еҢ–й’ҫгҖҒж°ўж°§еҢ–й’гҖҒж°ўж°§еҢ–й”ӮгҖҒеҸ”дёҒйҶҮй’гҖҒеҸ”дёҒйҶҮ й’ҫгҖҒеҸ”жҲҠйҶҮй’гҖҒеҸ”жҲҠйҶҮй’ҫзӯүпјӣд№ҹеҸҜд»ҘжҳҜжңүжңәзўұеҰӮдёүд№ҷиғәпјҢеҗЎе•¶зӯүгҖӮиҝӣдёҖжӯҘзҡ„пјҢиҜҘеҸҚеә”дҪ“зі»иҝҳеҢ…жӢ¬3пҪһ10еҖҚдәҺ3-ж°Ҝ-3-(4-ж°ҹиӢҜеҹә)дёҷзғҜйҶӣиҙЁйҮҸзҡ„жә¶еүӮпјҢ е…¶дёӯжә¶еүӮпјҡ3-ж°Ҝ-3-(4-ж°ҹиӢҜеҹә)дёҷзғҜйҶӣиҙЁйҮҸпјқmLпјҡgпјҢжүҖиҝ°жә¶еүӮдёәNMPгҖҒDMFгҖҒDMAcгҖҒеҗЎе•¶гҖҒд№ҷи…ҲгҖҒдёҷй…®гҖҒ1пјҢ4-дәҢж°§е…ӯзҺҜгҖҒеӣӣж°ўе‘Ӣе–ғгҖҒз”ІйҶҮгҖҒд№ҷйҶҮе’ҢејӮдёҷйҶҮдёӯзҡ„д»»дёҖз§ҚгҖӮиҝӣдёҖжӯҘзҡ„пјҢиҜҘеҸҚеә”зҡ„жё©еәҰдёә30в„ғпҪһ80в„ғгҖӮ 3пјү5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-зҫ§й…ёд№ҷй…ҜеңЁзўұзҡ„дҪңз”ЁдёӢеҸ‘з”ҹй…Ҝж°ҙи§ЈпјҢз»ҸеҠж°ҙпјҢй…ёеҢ–пјҢжҠҪ ж»ӨпјҢе№ІзҮҘеҲ¶еҫ—еҲ°5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-з”Ій…ёпјӣиҝӣдёҖжӯҘзҡ„пјҢзўұдёә1.0пҪһ2.0еҖҚдәҺ5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-зҫ§й…ёд№ҷй…Ҝж‘©е°”ж•°зҡ„ж—жңәзўұпјҢеҸҜд»Ҙдёәж°ўж°§еҢ–й”ӮгҖҒж°ўж°§еҢ–й’гҖҒж°ўж°§еҢ–й’ҫгҖҒзўій…ёй’гҖҒзўій…ёй’ҫдёӯд»»ж„ҸдёҖз§ҚжҲ–еҮз§ҚгҖӮиҝӣдёҖжӯҘзҡ„пјҢжӯҘйӘӨ3)зҡ„еҸҚеә”дҪ“зі»дёӯиҝҳеҢ…жӢ¬3пҪһ10еҖҚдәҺ5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-зҫ§й…ёд№ҷй…ҜиҙЁйҮҸзҡ„жә¶еүӮпјҢе…¶дёӯжә¶еүӮпјҡ5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©ж°ҹиӢҜеҹә)еҷ»еҗ©-2-зҫ§й…ёд№ҷй…ҜиҙЁйҮҸпјқmLпјҡgпјҢжүҖиҝ°зҡ„жә¶ еүӮдёәз”ІйҶҮгҖҒд№ҷйҶҮгҖҒејӮдёҷйҶҮгҖҒдёҷйҶҮгҖҒ1пјҢ4-дәҢж°§е…ӯзҺҜдёӯзҡ„д»»дёҖз§ҚгҖӮ 4пјү5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-з”Ій…ёеңЁй“ңзІүеӮ¬еҢ–дёӢпјҢеҠзғӯи„ұзҫ§пјҢз»ҸиҝҮж»ӨпјҢжһҗжҷ¶пјҢжҠҪж»ӨпјҢйҮҚз»“жҷ¶еҲ¶еҫ—2-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©гҖӮиҝӣдёҖжӯҘзҡ„пјҢй“ңзІүзҡ„з”ЁйҮҸдёә5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-з”Ій…ёиҙЁйҮҸзҡ„10пј…гҖӮиҝӣдёҖжӯҘзҡ„пјҢиҜҘеҸҚеә”жүҖз”Ёжә¶еүӮеҢ…жӢ¬дәҢз”ІдәҡзңгҖҒзҺҜдёҒзңгҖҒе–№е•үзӯүпјӣе…¶дҪ“з§Ҝз”ЁйҮҸдёәеә•зү©иҙЁ йҮҸзҡ„2-10еҖҚпјӣиҝӣдёҖжӯҘзҡ„пјҢеҸҚеә”жүҖз”Ёжё©еәҰ160в„ғ-250в„ғгҖӮ |
дёӢжёёдә§е“Ғ | 5-(4-ж°ҹиӢҜеҹә)еҷ»еҗ©-2-зҫ§й…ё-->еҚЎж јеҲ—еҮҖ дёӯй—ҙдҪ“ KG-1 |